Owners and managers of sites using cleanrooms can dramatically reduce their operating costs, thereby increasing their profits, through the implementation of energy- and resource-efficiency policies. Energy efficiency is the practice of using less energy to deliver the same goods and services without increasing production time or diminishing product quality. Energy efficiency is wise business practice in any industry, but it can be an especially fruitful venture in cleanrooms. Cleanrooms are inherently energy- and resource-intensive facilities.

A cleanroom is defined by ISO14644-1 as "a room in which the concentration of airborne particles is controlled, and which is constructed and used in a manner to minimize the introduction, generation, and retention of particles inside the room and in which other relevant parameters, e.g. temperature, humidity, and pressure, are controlled as necessary." The design of cleanroom HVAC systems is a specialty area requiring the unique understanding of cleanliness guidelines, airflow, room pressurization, code requirements, specialty equipment, precise control, and many more details.